Pharmacokinetic parameter estimates from basic and final models
| Basic model | Final model | |
| Clearance (l/h) | 0.0844 | 3.56 × weight / creatinine concentration |
| (%SE) | (11.3%) | (3.8%) |
| Interpatient variability on clearance | 67% | 22% |
| (%SE) | (18%) | (28%) |
| Volume (l) | 1.01 | 0.669 × weight |
| (%SE) | (11.4%) | (4.7%) |
| Interpatient variability on volume | 58% | 18% |
| (%SE) | (27%) | (46%) |
| Residual error on concentration (mg/l) | 4.80 | 4.53 |
| (%SE) | (13%) | (13%) |
NB variability in clearance and volume of distribution between individuals is expressed as a percentage coefficient of variation.
%SE = standard error of parameter estimate expressed as a percentage.