Periventricular leucomalacia: high frequency ventilation (HFV) versus conventional ventilation (CV)
| Reference | HFV event observed/ total No of patients | CV event observed/ total No of patients | Relative risk (95% CI) |
|---|---|---|---|
| HIFI, 1989 | 38/327 | 25/346 | 1.61 (0.99, 2.60) |
| Ogawa, 1993 | 1/46 | 4/46 | 0.25 (0.03, 2.15) |
| Gerstmann, 1996 | 4/56 | 3/55 | 1.31 (0.31, 5.58) |
| Wiswell, 1996 | 10/32 | 2/32 | 5.00 (1.19, 21.04) |
| Keszler, 1997 | 4/61 | 9/58 | 0.42 (0.14, 1.30) |
| Rettwitz-Volk, 1998 | 1/46 | 0/50 | 3.26 (0.14, 77.97) |
| Plavka (in press) | 2/21 | 1/20 | 1.90 (0.19, 19.40) |
| Total for all studies | 60/589 | 44/607 | 1.39 (0.96, 2.02) |
| Total for HLVS subgroup | 11/184 | 17/179 | 0.63 (0.30, 1.30) |
| Total for surfactant subgroup | 22/262 | 19/261 | 1.13 (0.63, 2.02) |
| Total for HFOV subgroup | 46/496 | 33/517 | 1.45 (0.95, 2.22) |
| Total for HFJV subgroup | 14/93 | 11/90 | 1.24 (0.59, 2.61) |
HFV=high frequency ventilation; HFOV=high frequency oscillatory ventilation; HFJV=high frequency jet ventilation; CV=conventional ventilation; RDS=respiratory distress syndrome; BPD=bronchopulmonary dysplasia; CLD=chronic lung disease; HLVS=high lung volume strategy; RR=relative risk; CI=confidence interval.