Pharmacokinetic parameters of paracetamol in preterm neonates after rectal single dose
| Parameter | 28–32 weeks (1) | 32–36 weeks (2) | p Value |
|---|---|---|---|
| Cmax (mg/l) | 12.5 (2.9) | 7.5 (4.0) | 0.001 |
| range | 7.5–18.0 | 1.5–13.6 | |
| Tmax(h)* | 3.9 | 5.1 | NS |
| range | 0.8–10.5 | 1.0–9.5 | |
| T½ (h) | 11.0 (5.7) | 4.8 (1.2) | 0.011 |
| range | 3.5–25.2 | 3.6–6.8 | |
| AUC (mg/h/l) | 95.1 (28.0) | 71.7 (41.7) | 0.046 |
| range | 29.0–160.6 | 17.5–134.6 | |
| Cl (l/h) | 0.10 (0.04) | 0.56 (0.66) | 0.04 |
| range | 0.03–0.17 | 0.13–1.70 |
Cmax, maximum concentration; Tmax, time to reach maximum concentration; T½, elimination half life; AUC, area under the concentration-time curve; Cl clearance. Data are shown as mean (SD) or as median*.