17α-hydroxyprogesterone concentrations in preterm infants: review of published findings
| Author Year | No of preterm infants | Time of collection | 17OHP (nmol/l) | Remarks | |||||
|---|---|---|---|---|---|---|---|---|---|
| Cacciariet al 17 1983 | Total 41 299 | Days 1–15 | Peak 13 pg/disk | Infant maturity and day of collection affect values | |||||
| preterm 3935 | range 13–5 pg/disk | ||||||||
| Wallace et al 9 1985 | 376 (direct method) | Second week after birth | Direct: median 31 nmol/l | Results were lower in extraction assay | |||||
| 118 (extraction method) | extraction: median 13.5 range 0–75 nmol/l | ||||||||
| Berry et al 12 1986 | 32 | Days 3,8,14 | Peak 130 nmol/l (day=3) | Upper limit: term infants—20 nmol/l | |||||
| range 20–80 nmol/l | preterm—200 nmol/l | ||||||||
| Laressonet al 10 1988 | Total 22 400 | After 72 h (medain 5 days) | n=201–>100 nmol/l | Correlation with gestational age | |||||
| (preterm + full term) | n=13–>400 nmol/l | ||||||||
| Thompson et al 3 1989 | 89 (<2500 g) | Days 1–24 | n=11–>30 nmol/l | Day of collection did not influence results | |||||
| Lee et al 111989 | 22 (13 healthy, 9 sick) | Days 2–5 | Healthy 28.5 (6.2) nmol/l | Concentrations are higher in sick preterm infants | |||||
| mean (SD) sick 42.2 (7.2) nmol/l | |||||||||
| Knudtzonet al 17 1991 | 26 | Days 3–17 (mean 7.7) | Mean (SD) 53.3 (6.3) nmol/l | Negative correlation with gestational age and birth weight | |||||
| Ohkuboet al 131992 | 836 | Days 3 to 96 | <29 w—2.0 (1.39) nmol/l | ELISA | |||||
| 30–34 w—1.3 (0.85) nmol/l | |||||||||
| 35–36 w—0.82 (0.85) nmol/l | |||||||||
| (log values) | |||||||||
| Hingreet al 18 1994 | 25 (<1250 g) | Day 4 | Mean (SD)=11.4 (11.1) nmol/l | High concentrations in very low birthweight infants | |||||
| Al Saediet al 4 1995 | 39 healthy <31 weeks | Once a week until age 37 weeks | Mean (SD)=11.4 (11.1) nmol/l | Predicted 17OHP concentrations: | |||||
| range 1.4–82.5 nmol/l | 9.4–13—initial | ||||||||
| 5.2–5.3—35 to 56 days of age | |||||||||
| Allen et al 151997 | 149 684 | At time of discharge | Multitiered reporting scheme: | Weight adjusted criteria reduced the false positive results without diminishing sensitivity | |||||
| 1299 g—499.3 nmol/l | |||||||||
| 1300–1699 g—408.5 nmol/l | |||||||||
| 1700–2200 g—272.3 nmol/l | |||||||||
| >2200 g—121.0 nmol/l | |||||||||
| Linder et al 1999 (present study) | 66 | Once a week during the first month and then every two weeks until age 3 months | 17OHP (nmol/l) | 17OHP concentrations decline to full term concentrations during the first three months of life. Birthweight and gestational age affect level | |||||
| Day | <29 week | 29–30 week | 31–32 week | >33 week | |||||
| 1 | 179.1 | 98.3 | 99.6 | 78.1 | |||||
| 7 | 138.9 | 46.3 | 53.3 | 29.9 | |||||
| 14 | 63.2 | 40.2 | 42.9 | 29.7 | |||||
| 21 | 45.1 | 40.2 | 44.3 | 31.2 | |||||
| 28 | 42.1 | 48.7 | 48.1 | 32.1 | |||||
| 45 | 37.5 | 35.4 | 35.4 | 29.7 | |||||
| 60 | 35.0 | 26.9 | 25.1 | 17.8 | |||||
| 90 | 32.7 | 23.6 | 16.9 | 13.0 | |||||