The diagnostic criteria for hyperinsulinism
| Glucose requirements > 6–8 mg/kg/min to maintain blood glucose above 2.6–3 mmol/litre |
| Laboratory blood glucose < 2.6 mmol/litre |
| Detectable insulin at the point of hypoglycaemia with raised C peptide |
| Inappropriately low blood free fatty acid and ketone body concentrations at the time of hypoglycaemia |
| Glycaemic response after the adminstration of glucagon when hypoglycaemic |
| Absence of ketonuria |