Effects of ventilation status and clinical stability on GFR, and on renal processing of glucose, water, and sodium
| Ventilation status | ||||||
|---|---|---|---|---|---|---|
| Babies never vs currently ventilated | Babies currently vs previously ventilated | |||||
| Never (n = 23) | Currently (n = 22) | Currently | Previously | |||
| (pairs, n = 12) | ||||||
| GFR, ml/kg/min | 0.97 (0.06)† | 0.79 (0.04) | 0.79 (0.06)† | 0.91 (0.06) | ||
| Glucose | ||||||
| fractional excretion, % | 2.1 (0.8)† | 7.6 (2.0) | 10.1 (2.9) | 9.3 (3.7) | ||
| Water processing | ||||||
| (i) intake, ml/kg/day | 144 (9.4) | 124 (7.7) | 133 (12.7)* | 171 (14.3) | ||
| (ii) “net difference”, ml/kg/day2-153 | 18.8 (10.3) | 34.6 (12.3) | 29.7 (16.5) | 30.1 (19.6) | ||
| (iii) fractional excretion, % | 9.8 (0.9) | 8.1 (0.9) | 9.0 (1.0) | 10.9 (1.3) | ||
| (iv) free clearance, ml/kg/day | 81 (11.0)‡ | 26 (8.3) | 31 (14.1) | 79 (8.7) | ||
| Sodium processing | ||||||
| (i) “net difference”, mmol/kg/day2-153 | −0.17 (0.38) | −1.27 (0.63) | −1.69 (0.84) | −2.06 (0.69) | ||
| (ii) fractional excretion, % | 1.6 (0.2) | 2.5 (0.5) | 2.9 (0.9) | 2.7 (0.3) | ||
| Clinical stability | |||||||
|---|---|---|---|---|---|---|---|
| Including ventilated and unventilated babies | Ventilated babies only | ||||||
| Stable (n = 35) | Unstable (n = 10) | Stable (n = 12) | Unstable (n = 10) | ||||
| 0.91 (0.04) | 0.76 (0.07) | 0.81 (0.06) | 0.76 (0.07) | ||||
| 5.2 (1.5) | 3.6 (1.3) | 10.9 (3.2) | 3.6 (1.3) | ||||
| 141 (7.6)* | 111 (4.1) | 135 (13.1)* | 111 (4.1) | ||||
| 22.6 (6.9) | 40.8 (12.8) | 29.5 (20.0) | 40.8 (12.8) | ||||
| 9.6 (0.7) | 6.6 (1.1) | 9.3 (1.3) | 6.6 (1.1) | ||||
| 69 (9.3)† | 17 (7.7) | 39 (15.1) | 17 (7.7) | ||||
| −0.74 (0.36) | −0.64 (1.13) | −1.79 (0.65) | −0.64 (1.13) | ||||
| 2.0 (0.2) | 2.2 (0.9) | 2.8 (0.4) | 2.2 (0.9) | ||||
All values are shown as mean (SE).
P values: * < 0.05, † < 0.01, ‡ < 0.001.
↵2-153 Note: “net differences” refer to the differences between the daily estimated intakes and excretion rates of sodium or water, measured at the time of daily sampling. Unlike a true balance, it does not take insensible or stool losses into account.