Case No | Neonatal disease | HSV-DNA | Aciclovir/no treatment | CT/MRI/HUS | Follow up neurodevelopmental outcome/years | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CSF | S | ||||||||||
Maternal primary HSV-1 infection, no previous HSV infection with either type | |||||||||||
1 | DISS* | ND | +(5) | None | ND | Normal+ keratitis/14y* | |||||
2 | CNS* | ND | +(7) | None | ND | Normal/14y | |||||
3 | CNS* | ND | +(4) | Aciclovir | ND | Normal/1y | |||||
Maternal secondary HSV-1 infection (previous infection with HSV-1) | |||||||||||
4 | CNS* | − | +(4) | Aciclovir | Normal | Normal/ 7y* | |||||
5 | DISS* | ND | +(4) | None | ND | MMR/14y* | |||||
External source HSV-1 infection (no maternal infection) | |||||||||||
6 | DISS | + | +(10) | Aciclovir | Normal | Normal/1y | |||||
7 | CNS* | + | +(1) | Aciclovir | Abnormal | Normal/1y | |||||
Maternal primary HSV-2 infection, no previousHSV infection with either type | |||||||||||
8 | CNS | ND | −(6) | None | ND | CP/18y* | |||||
9 | DISS | ND | +(2) | None | ND | Dead/1w | |||||
10 | DISS | − | ND | None | ND | Dead/1w | |||||
11 | CNS | + | +(1) | Aciclovir | Abnormal | Dead/4y | |||||
12 | DISS,cong* | − | ND | Aciclovir | Abnormal | CP+SMR/2y* | |||||
Maternal primary HSV-2, previous HSV-1 infection | |||||||||||
13 | CNS | ND | −(5) | None | ND | CP+SMR/8y | |||||
14 | CNS* | ND | −(3) | None | Abnormal | CP+SMR/14y* | |||||
15 | CNS* | − | −(6) | Aciclovir | ND | Normal/7y* | |||||
16 | CNS* | − | −(4) | Aciclovir | Abnormal | CP+SMR/11y* | |||||
17 | CNS* | + | ND | Aciclovir | Abnormal | CP+SMR/4y* | |||||
18 | CNS | + | −(2) | Aciclovir | Abnormal | CP/2y* | |||||
Maternal secondary HSV-2 infection, (previous infection with HSV-2) | |||||||||||
19 | CNS* | ND | −(9) | None | Abnormal | CP/18y* | |||||
20 | CNS | − | +(4) | Aciclovir | Abnormal | CP+MMR/14y* | |||||
21 | CNS* | + | +(2) | Aciclovir | Abnormal | CP+SMR/12y* | |||||
22 | CNS | + | −(3) | Aciclovir | Abnormal | normal/10y* | |||||
23 | CNS* | + | +(3) | Aciclovir | Abnormal | CP/6y* | |||||
24 | CNS* | − | +(4) | Aciclovir | Abnormal | Normal+ keratitis/7y | |||||
25 | CNS* | + | +(6) | Aciclovir | Abnormal | Normal/1y* | |||||
26 | CNS | + | +(4) | Aciclovir | Abnormal | Normal /3.5y | |||||
27 | CNS | + | +(5) | Aciclovir | Abnormal | CP+SMR/6y* | |||||
28 | CNS | + | +(7) | Aciclovir | Abnormal | Normal/1.5y | |||||
29 | CNS | + | ND | Aciclovir | Abnormal | CP+/4y* | |||||
30 | CNS | + | +(6) | Aciclovir | Abnormal | CP+SMR/10y | |||||
31 | CNS | + | −(3) | Aciclovir | Abnormal | CP+SMR/8y* | |||||
32 | CNS | + | −(20) | Aciclovir | Abnormal | CP+SMR/10y* | |||||
33 | CNS | + | +(3) | Aciclovir | Abnormal | CP+SMR/7y | |||||
34 | CNS* | + | +(1) | Aciclovir | Abnormal | dead/2.5y | |||||
35 | SEM* | + | ND | Aciclovir | Normal | Normal+ keratitis/3y | |||||
36 | CNS | + | ND | Aciclovir | Abnormal | CP/1.5y |
S = serum; CSF = cerebrospinal fluid;
1-151 figures in parentheses represent sampling day after onset of disease ND = no specimens/not done; CP = cerebral palsy; SMR/MMR = severe/mild mental retardation; Cong = congenital; Normal = No neurodevelopmental abnormality; CT/ MRI/HUS = computed tomography/ magnetic resonance imaging /head ultrasound; * = neonatal and/or subsequent recurrent vesicles.