Bile acid (μmol/mmol Cr) | 0 days (n=6) | 3 days (n=6) | 7 days (n=6) | 1 month (n=6) | 2 months (n=6) | 3 months (n=6) |
---|---|---|---|---|---|---|
Usual bile acids | 0.40 (0.19)a b | 2.69 (2.67) | 1.84 (1.24) | 3.47 (1.83) | 1.96 (0.74)c | 1.12 (0.37) |
% in total bile acids | (14.19 (5.74)c d e) | (13.60 (7.82)c d f) | (17.36 (8.43)b g) | (29.10 (5.45)) | (23.19 (2.75)) | (25.61 (3.86)) |
Fetal bile acids | 0.54 (0.19)b h i | 6.26 (3.81)g | 5.59 (3.55) | 6.29 (6.21)g | 3.87 (1.64) | 1.93 (0.70) |
% in total bile acids | (18.63 (5.86)a b c j k) | (35.95 (19.02)) | (41.40 (16.34)) | (44.66 (11.42)) | (45.96 (10.01)) | (43.88 (5.40)) |
Ursodeoxycholic acid | 0.04 (0.02)b c f | 0.08 (0.04)b e g | 0.14 (0.07)b | 0.35 (0.18) | 0.27 (0.10) | 0.29 (0.24) |
% in total bile acids | (1.48 (0.92)e l m) | (0.52 (0.33)b f m) | (1.99 (1.77)m) | (3.25 (1.47)c) | (3.45 (1.36)c) | (5.90 (1.98)) |
3-oxo-Δ1 bile acid | 1.09 (0.88)2-a | 6.94 (4.83)e g l | 5.63 (8.89)e g | 0.79 (0.37) | 0.54 (0.21) | 0.35 (0.12) |
% in total bile acids | (31.44 (17.24)d k m) | (34.57 (18.00)d k m) | (22.93 (9.55)e g l) | (6.81 (1.76)) | (6.60 (2.00)) | (8.17 (1.68)) |
3-oxo-Δ4 bile acids | 1.15 (1.05) | 3.27 (3.15) | 6.26 (13.75) | 2.00 (1.38) | 1.81 (1.24) | 0.81 (0.62) |
% in total bile acids | (34.27 (16.22)g h i l) | (15.36 (9.30)) | (16.32 (17.19)) | (16.18 (5.33)) | (20.80 (11.76)) | (16.44 (4.48)) |
Total bile acids | 3.22 (1.86)a i | 19.24 (8.93)g | 19.46 (24.81)g | 12.91 (9.46) | 8.45 (2.88) | 4.50 (1.93) |
Usual bile acids: CA, CDCA, DCA, LCA. Fetal bile acids: CA-1β-ol, CDCA-1β-ol, HCA, Δ5-3β-ol. 3-oxo-Δ1 bile acid: Δ1-3-one. 3-oxo-Δ4 bile acids: Δ4-3-one, Δ4, 6 -3-one.
↵2-a P < 0.05 vs 3 days; b P < 0.01vs 1 month; c P < 0.01 vs 3 months; d P < 0.001 vs 1 month; eP < 0.05 vs 2 months, f P < 0.01vs 2 months; g P < 0.05 vs 3 months; h P < 0.01 vs 3 days; i P < 0.05 vs 7 days; j P < 0.01 vs7 days; k P < 0.001 vs 2 months,l P < 0.05 vs 1 month; m P < 0.001 vs 3 months.