Table 2

Characteristics of trials included in the review: trials where dexamethasone has begun 7–14 days of age

AuthorYearDouble blindedDose (mg/kg/day)Course length (day)Start ageNo of patientsCharacteristics
Durandet al 34 1995No0.5 (3), 0.25 (3), 0.1 (3)77–14 d43501–1500 g; 24–32 w; MV at 7–14  d; surfactant 26% in dex and  65% in control received steroids
Brozanski et al 35 1995Yes0.5 (3) every 10 days, until*36 w PMA or no O2  therapyUntil 36 w PMA7 d78<1500 g; stratified <1000, >1001;  surfactant; MV No crossover
Kari et al 36 1993Yes0.5 (7)710 d41<1500 g; >24 w; MV at 10 days;  only 3 patients in in dex group  and 1 control received surfactant  33% of controls received steroids
Cummings et al 37 1989Yes0.5 (3), 0.3 (3), then ↓ by 10% every 3 days until  0.1 and then on alternate days for 1 week4214 d36<1250 g; <30 w; MV at 14 days;  randomised to three groups, 42  d, 18 d, and control
18
  • Figures in parentheses indicate days. PMA = post menstrual age; dex = dexamethasone.