Mean (SEM) values averaged over 240 min for the first, third, and fifth doses of dexamethasone. In parenthesis: mean baseline values before dexamethasone
| Before dexamethasone (baseline) | First dose | Third dose | Fifth dose | p Value2-a | |
|---|---|---|---|---|---|
| CBF | (22.9 (2.0)) | 31.1 (2.2) | 33.7 (1.9) | 36.9 (1.6)2-b | 0.0024 |
| CBV | (2.3 (0.2)) | 3.2 (0.2) | 3.3 (0.2) | 3.2 (0.2) | NS |
| MAP | (47 (3)) | 50 (1) | 56 (1)2-c | 56 (1)2-c | 0.001 |
| HR | (155 (3)) | 154 (1.5) | 140 (2)2-c | 144 (2.2)2-c | 0.001 |
| TcPCO2 | (67.6 (10.6)) | 56.9 (2.3) | 52.2 (1) | 47.6 (0.8)2-b | 0.001 |
CBF: cerebral blood flow, CBV: cerebral blood volume, MAP: mean arterial blood pressure, HR: heart rate, TcPCO2: transcutaneous PCO2. The values for each variable were calculated by averaging the values measured at 0, 10, 30, 60, 120, 180 and 240 min for the first, third, and fifth doses of dexamethasone administered.
↵2-a Analysis of variance (ANOVA) of two factors for repeated measurments.
↵2-b α=0.05 versus first dose (Bonferroni test).
↵2-c α=0.01 versus first dose (Bonferroni test).