Table 3

Comparison of the sensitivity, specificity, positive and negative predictive values of the biochemical tests using the calculated optimal cutoff values and the manufacturers’ recommended values (in parentheses) during the first 48 hours of suspected clinical sepsis

Test(s)		Day 0			Day 1
Test(s)		Sensitivity	Specificity		PPV	NPV	Sensitivity	Specificity	PPV	NPV
CRP	0.6 (0.6)	1.0 (0.96)	1.0 (0.93)	0.75 (0.77)	0.82 (0.82)	0.96 (0.93)	0.95 (0.90)	0.87 (0.86)
IL-6	0.89 (0.93)	0.96 (0.71)	0.95 (0.73)	0.91 (0.93)	0.67 (0.82)	0.89 (0.64)	0.84 (0.65)	0.77 (0.81)
TNFα	0.82 (0.82)	0.86 (0.82)	0.82 (0.79)	0.85 (0.85)	0.82 (0.87)	0.93 (0.84)	0.90 (0.82)	0.86 (0.88)
IL1-β	0.82 (0.43)	0.68 (0.95)	0.68 (0.87)	0.82 (0.67)	0.58 (0.18)	0.84 (0.96)	0.75 (0.80)	0.71 (0.56)
E-selectin	0.64 (1.0)	0.89 (0.16)	0.83 (0.49)	0.75 (1.0)	0.51 (0.96)	0.93 (0.20)	0.85 (0.49)	0.70 (0.84)
CRP/IL-6	0.93 (0.95)	0.96 (0.70)	0.95 (0.71)	0.95 (0.95)	0.93 (0.96)	0.88 (0.63)	0.86 (0.67)	0.94 (0.95)
CRP/TNFα	0.91 (0.91)	0.86 (0.80)	0.84 (0.79)	0.92 (0.91)	0.97 (0.98)	0.89 (0.79)	0.88 (0.79)	0.98 (0.98)
IL6/TNFα	0.95 (0.95)	0.84 (0.63)	0.83 (0.68)	0.96 (0.94)	0.91 (0.93)	0.84 (0.59)	0.82 (0.65)	0.92 (0.91)
CRP/IL6/TNFα	0.95 (0.95)	0.84 (0.59)	0.82 (0.65)	0.96 (0.94)	0.98 (0.98)	0.80 (0.59)	0.80 (0.66)	0.98 (0.97)

PPV = positive predictive value; NPV = negative predictive value.