anti-D level related to outcome of pregnancy
| Grade of HDN | < 0.25 IU/ml enzyme only | < 0.25 IU/ml IAT (and enzyme) | 0.25-1 IU/ml | 1-4 IU/ml | 4-15 IU/ml | > 15 IU/ml | Total (RhD negative baby) |
|---|---|---|---|---|---|---|---|
| DAT negative | 43 | 3-1607 | 3 | 1 | 3 | 3 | 60 (38) |
| DAT positive but no treatment | 3-1504 | 2 | 4 | 2 | 1 | 13 (3) | |
| Phototherapy | 3-1502 | 3 | 1 | 2 | 8 | ||
| Hb < 120 g/l no Tx | 3-1501 | 1 | 2 | 4 | |||
| Exchange/top up Tx | 1 | 1 | 4 | 6 | |||
| IUT/LB | 3 | 3 | |||||
| IUT/IUD | 1 | 1 | |||||
| IUD 15-24 weeks gestation | 1 | 1 | |||||
| Fetal loss < 15 weeks | 1 | 1 | 2 | 4 | |||
| Total | 50 | 11 | 11 | 5 | 7 | 16 | 100 (41) |
↵3-150 In 7 babies from mothers with anti-D levels < 0.25 IU/ml, detected only by enzyme testing, the positive DAT may have been due to ABO incompatibility.
↵3-160 Includes one stillbirth due to cardiac abnormality.
NB: Babies with a negative DAT from mothers with anti-D levels > 0.25 IU/ml, were also RhD negative.
DAT = direct antiglobulin test; IAT = indirect antiglobulin test; enz = enzyme tests; Hb = haemoglobin; Tx = exchange or top-up transfusion; IUT = intrauterine transfusion; IUD = intrauterine death; LB = live birth.