Map | FIO2 | OI | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Treated | Control | Treated | Control | Treated | Control | ||||||
0 | 9 (4-21)2-150 | 7 (3-12) | 0.45 (0.22-1.0) | 0.37 (0.21-0.72) | 7.9*** (1.6-46.7) | 3.1 (1.2-11.5) | |||||
30 minutes | 9 (4-21)** | 7 (3-12) | 0.36 (0.21-1.0) | 0.37 (0.21-0.72) | 6.3 (1.2-45.7) | 3.2 (1.2-16.6) | |||||
1 hour | 9 (4-22) | 7 (3-12) | 0.36 (0.21-1.0) | 0.37 (0.21-0.86) | 6.7 (1.3-46.8) | 3.5 (1.1-14.6) | |||||
2 hours | 9 (4-19) | 6 (3-12) | 0.38 (0.21-1.0) | 0.33 (0.21-0.78) | 5.4 (1.3-39.6) | 3.0 (1.4-14) | |||||
4 hours | 9 (4-21) | 5 (3-11) | 0.36 (0.21-1.0) | 0.35 (0.22-0.83) | 5.3 (1.3-60.0) | 3.2 (2.1-105) | |||||
24 hours | 7 (0-21) | 5 (0-13) | 0.41 (0.21-1.0) | 0.31 (0.21-0.88) | 6.0 (1.5-28.8) | 5.0 (1.1-11.3) | |||||
48 hours | 6 (0-18) | 6 (0-11) | 0.37 (0.21-1.0) | 0.36 (0.21-1.0) | 5.2 (2.2-23.8) | 9.7 (2.1-23.2) | |||||
72 hours | 6 (0-21) | 6 (0-12) | 0.37 (0.21-1.0) | 0.32 (0.21-1.0) | 4.4 (1.6-46.7) | 4.1 (1.2-23.5) | |||||
96 hours | 4 (0-16) | 5 (0-14) | 0.32 (0.21-1.0) | 0.39 (0.21-0.92) | 3.5 (1.3-8.3) | 5.3 (1.2-25.3) | |||||
Day 7 | 0 (0-11) | 5 (0-11) | 0.30 (0.21-0.88) | 0.35 (0.21-0.77) | 9.5 (6.7-15.1) | 5.6 (2.9-12.2) |
PaCO2 | MBP | AT:RVET | |||||||
---|---|---|---|---|---|---|---|---|---|
Treated | Control | Treated | Control | Treated | Control | ||||
49 (28-74) | 44 (25-68) | 34 (29-48) | 41 (30-50) | 0.28 (0.16-0.41) | 0.30 (0.20-0.45) | ||||
48 (29-68) | 47 (28-70) | 34 (28-51) | 40 (34-60) | 0.30 (0.22-0.48) | 0.31 (0.21-0.43) | ||||
48 (27-69) | 46 (31-59) | 40 (25-55) | 40 (31-57) | 0.31 (0.18-0.46) | 0.29 (0.12-0.38) | ||||
47 (31-56) | 48 (33-59) | 38 (26-53) | 45 (30-60) | 0.28 (0.22-0.48) | 0.29 (0.18-0.39) | ||||
45 (26-68) | 45 (34-66) | 40 (30-46) | 40 (32-54) | 0.30 (0.18-0.43) | 0.28 (0.21-0.4) | ||||
43 (31-59) | 43 (30-71) | 38 (28-46) | 40 (32-52) | 0.32 (0.20-0.43) | 0.31 (0.21-0.41) | ||||
48 (29-53) | 43 (28-94) | 0.32 (0.20-0.41) | 0.31 (0.20-0.41) | ||||||
49 (36-64) | 43 (29-95) | 0.30 (0.18-0.39) | 0.29 (0.24-0.41) | ||||||
0.36 (0.20-0.39) | 0.32 (0.21-0.43) | ||||||||
0.29 (0.26-0.34) | 0.34 (0.25-0.45) |
Values expressed as median (range).
MAP = mean airway pressure (cm H2O); FIO2 = fractional inspired oxygen concentration; PaCO2 = arterial partial pressure of CO2 (mm Hg); MBP = mean arterial blood pressure (mm Hg).
↵2-150 p = 0.03 vs controls; ** p = 0.04 vscontrols; *** p = 0.02 vs controls.