RT Journal Article
SR Electronic
T1 Functional cardiac MRI in preterm and term newborns
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F86
OP F91
DO 10.1136/adc.2010.189142
VO 96
IS 2
A1 Alan M Groves
A1 Gaia Chiesa
A1 Giuliana Durighel
A1 Stephen T Goldring
A1 Julie A Fitzpatrick
A1 Sergio Uribe
A1 Reza Razavi
A1 Jo V Hajnal
A1 A David Edwards
YR 2011
UL http://fn.bmj.com/content/96/2/F86.abstract
AB Objective Objective To use cardiac MRI techniques to assess ventricular function and systemic perfusion in preterm and term newborns, to compare techniques to echocardiographic methods, and to obtain initial reference data. Design Design Observational magnetic resonance and echocardiographic imaging study. Setting Setting Neonatal Unit, Queen Charlotte's and Chelsea Hospital, London, UK. Patients Patients 108 newborn infants with median birth weight 1627 (580–4140) g, gestation 32 (25–42) weeks. Results Results Mean (SD) flow volumes assessed by phase contrast (PC) imaging in 28 stable infants were left ventricular output (LVO) 222 (46), right ventricular output (RVO) 219 (47), superior vena cava (SVC) 95 (27) and descending aorta (DAo) 126 (32) ml/kg/min, with flow being higher at lower gestational age. Limits of agreement for repeated PC assessment of flow were LVO ±50.2, RVO ±55.5, SVC ±20.9 and DAo ±26.2 ml/kg/min. Mean (SD) LVO in 75 stable infants from three-dimensional models were 245 (47) ml/kg/min, with limits of agreement ±58.3 ml/kg/min. Limits of agreement for repeated echocardiographic assessment of LVO were ±108.9 ml/kg/min. Conclusions Conclusions Detailed magnetic resonance assessments of cardiac function and systemic perfusion are feasible in newborn infants, and provide more complete data with greater reproducibility than existing echocardiographic methods. Functional cardiac MRI could prove to be a useful research technique to study small numbers of newborn infants in specialist centres; providing insights into the pathophysiology of circulatory failure; acting as an outcome measure in clinical trials of inotropic intervention and so guiding clinical practice in the wider neonatal community.