Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis

J Pediatr. 1993 Mar;122(3):460-3. doi: 10.1016/s0022-3476(05)83441-9.

Abstract

Two infants with subcutaneous fat necrosis had hypercalcemia that normalized during glucocorticoid treatment. The combination of hypercalcemia, normal concentration of 25-hydroxyvitamin D, an elevated concentration of 1,25-dihydroxyvitamin D, a suppressed parathyroid hormone level, and low-normal bone turnover indicated abnormal 1,25-dihydroxyvitamin D production with increased intestinal absorption of calcium. Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia.

Publication types

  • Case Reports

MeSH terms

  • Adipose Tissue*
  • Bone and Bones / metabolism
  • Calcitriol / blood*
  • Fat Necrosis / blood*
  • Fat Necrosis / etiology
  • Female
  • Humans
  • Hypercalcemia / etiology*
  • Infant, Newborn
  • Parathyroid Hormone / blood

Substances

  • Parathyroid Hormone
  • Calcitriol