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2021, Journal of Lipid ResearchCitation Excerpt :Phosphatidylinositol is a comparatively large component of the membranes of most cells in metazoans ranging from 4 to 20 mol% of total phospholipid (1, 14), and analysis of phosphatidylinositol in six different mammalian species shows 4.4–6.4% mol% of total retina phospholipid (14–17). Studies have shown that retinal ROS membranes contain lower levels of PI than do retinal pigment epithelium (RPE) cells (18) and ER membranes isolated from bovine retinas (19). Recently, Wensel’s laboratory reported that ROSs and fragments of inner segments contain PI(3)P at 0.0035 mol% and PI(4)P and PI(4,5)P2 on the order of 0.04 mol%, 10-fold higher than the levels of PI(3)P of total phospholipid (14).
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Department of Biology, Amherst College, Amherst, Massachusetts, U.S.A.