Biochemical and Molecular Medicine
Regular ArticleSequential Evaluation of Plasma Retinol-Binding Protein Response to Vitamin A Administration in Very-Low-Birth-Weight Neonates
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Systematic review and meta-analysis of the relative dose-response tests to assess vitamin a status
2021, Advances in NutritionESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins
2018, Clinical NutritionCitation Excerpt :Vitamin A status may be also assessed as serum retinol (normal range 1–3 μmol/l measured by HPLC) or the concentration of RBP (<0.48 mmol/L is associated with severe vitamin A deficiency). Both the plasma RBP response [12,13] and the relative rise in serum retinol concentration [14] following intramuscular (I.M.) vitamin A administration have been described as useful tests to assess functional vitamin A status. Under stress conditions, serum retinol is not reliable and it is recommended to use the RBP/transthyretin ratio instead [9].
Vitamin A Metabolism in the Fetus and Neonate
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionAssessment of vitamin A nutritional status in newborn preterm infants
2007, NutritionCitation Excerpt :Similar to humans, the RDR assay agreed with liver biopsies as an indication of vitamin A status, especially at 28 d of life [36]. The RDR test has been successfully applied to preterm newborns as a method for the assessment of vitamin A status [17,32,33,38]; however, we are seeking a simpler method to verify vitamin A nutritional status in these patients. In the present study, we analyzed the possibility that serum retinol, RBP, or TTR levels or even combined levels in ratios (retinol/RBP, retinol/TTR, and RBP/TTR) could be as useful as the RDR test in identifying preterm newborns with vitamin A deficiency.
Vitamin A Metabolism in the Fetus and Neonate
2003, Fetal and Neonatal Physiology: Third Edition