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Adverse effects of small for gestational age differ by gestational week among very preterm infants
  1. Erik A Jensen1,2,
  2. Elizabeth E Foglia1,2,
  3. Kevin C Dysart1,2,
  4. Rebecca A Simmons1,2,
  5. Zubair H Aghai3,
  6. Alison Cook4,
  7. Jay S Greenspan3,
  8. Sara B DeMauro1,2
  1. 1Department of Pediatrics, Division of Neonatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
  2. 2The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  3. 3Division of Neonatology, Nemours/Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  4. 4Optum Corporation, Eden Prairie, Minnesota, USA
  1. Correspondence to Dr Erik A Jensen, Department of Pediatrics, Division of Neonatology, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA; jensene{at}email.chop.edu

Abstract

Objective To characterise the excess risk for death, grade 3–4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3–5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation.

Methods Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies. SGA was defined as a birth weight <10th percentile. The excess outcome risk independently associated with SGA birth among SGA babies was assessed using adjusted risk differences (aRDs).

Results Of 6708 infants sampled from 717 US hospitals, 743 (11.1%) were SGA. SGA compared with non-SGA infants experienced higher unadjusted rates of each study outcome except grade 3–4 IVH among survivors. The excess risk independently associated with SGA birth varied by outcome and gestational age. The highest aRD for death (0.27; 95% CI 0.13 to 0.40) occurred among infants born at 24 weeks gestation and declined as gestational age increased. In contrast, the peak aRDs for BPD among survivors (0.32; 95% CI 0.20 to 0.44) and the composites of death or BPD (0.35; 95% CI 0.24 to 0.46) and death or major morbidity (0.35; 95% CI 0.24 to 0.45) occurred at 27 weeks gestation. The risk-adjusted probability of dying or developing one or more of the evaluated morbidities among SGA infants was similar to that of non-SGA infants born approximately 2–3 weeks less mature.

Conclusion The excess risk for neonatal morbidity and mortality associated with being born SGA varies by adverse outcome and gestational age.

  • bronchopulmonary dysplasia
  • intra-uterine growth restriction
  • intraventricular hemorrhage
  • premature Infant
  • retinopathy of prematurity

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Footnotes

  • Contributors EAJ conceptualised the study design, performed the statistical analysis, wrote the first and final drafts of the manuscript and approved the final manuscript as submitted. EAJ had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. EEF, KCD and SBD conceptualised the study design and data analysis, participated in data interpretation, critically reviewed the manuscript and approved the final manuscript as submitted. RAS, ZHA, AC and JSG participated in the study design and data interpretation, critically reviewed the manuscript and approved the final manuscript as submitted.

  • Funding EAJ was supported by a grant from the National Health, Lung, and Blood Institute (K23HL136843). EEF was supported by a grant from the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (K23HD084727).

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The Thomas Jefferson University Institutional Review Board certified the use of this deidentified dataset as non-human subjects research.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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