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Management of early-onset neonatal infections
  1. Tanya Naydeva-Grigorova,
  2. Azhar Manzoor,
  3. Mansoor Ahmed
  1. Department of Paediatrics, Queen's Hospital, Burton Upon Trent, Staffordshire, UK
  1. Correspondence to Dr Mansoor Ahmed, Queen's Hospital, Belvedere Road, Burton-upon-Trent, Staffordshire DE13 0RB, UK; mansoor.ahmed{at}

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Early-onset neonatal infection (EONI) refers to an infection arising within first 72 h after birth. In August 2012, the National Institute of Health and Care Excellence (NICE) published guideline on the use of antibiotics to prevent and treat early-onset bacterial infection in newborn babies.1 Key recommendations included treating suspected EONI as quickly as possible and minimise antibiotic exposure in babies who do not have EONI. NICE recommends measuring C-reactive protein (CRP) at presentation when starting antibiotics and repeating CRP 18–24 h later. Furthermore, it suggests stopping antibiotics at 36 h if baby is clinically well, blood culture (BC) is negative and CRP values/trends …

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