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Prospective controlled study to evaluate cryocontact therapy for infantile haemangioma in preterm infants
  1. Rangmar Goelz1,
  2. Monika Moll1,
  3. Christoph Meisner2,
  4. Martin Röcken3,
  5. Christian F Poets1,
  6. Matthias C Moehrle3
  1. 1Department of Neonatology, University Childrens's Hospital, Tuebingen, Germany
  2. 2Institute of Medical Biometry, Tuebingen, Germany
  3. 3University Hospital of Dermatology, Tuebingen, Germany
  1. Correspondence to Dr Rangmar Goelz, Department of of Neonatology, University Childrens Hospital, Calwerstrasse 7, Tuebingen D-72076, Germany; Rangmar.Goelz{at}

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Despite the high prevalence of infantile haemangioma (IH) of preterm infants, methods for treating it have not yet been evaluated in controlled trials.1 Therefore, we conducted a prospective controlled study, comparing nitrogen-cooled cryocontact therapy (NCCT,−196°C) for early treatment of IH in preterm infants with no treatment.

From 1 August 2004 to 31 December 2008, we allocated IH of infants ≤34 weeks gestational age with at least two IH into either a cryocontact or a control group, thus using intraindividual controls to exclude interpersonal differences potentially affecting growth. If IH appeared simultaneously, they were numbered from head to foot; even numbers were treated, odd numbers served as controls. In sequentially erupting IH, always the second one …

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