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C-reactive protein (CRP) responses in neonates with hypoxic ischaemic encephalopathy
  1. Sanjeev Rath1,
  2. Raju Narasimhan2,
  3. Colin Lumsden2
  1. 1Neonatal Unit, Women's and Children's Hospital, Wirral University Teaching Hospital NHS Foundation Trust, Wirral, Merseyside, UK
  2. 2Neonatal Unit, Royal Preston Hospital, Preston, Lancashire, UK
  1. Correspondence to Dr Sanjeev Rath, Neonatal Unit, Women's and Children's Hospital, Wirral University Teaching Hospital NHS Foundation Trust, Upton Road, Wirral, Merseyside CH49 5PE, UK; sanjeev_rath{at}hotmail.com

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Intrapartum hypoxic ischaemic insult remains an important cause of perinatally acquired brain injury in full term neonates. The risk of death or severe neurological impairment following hypoxia–ischaemia is 0.5–1.0/1000 live births in the UK (≈750 neonates/year).1 It is routine practice to commence antibiotics in these neonates pending blood culture results. However, the duration of antibiotic therapy in those neonates with negative blood cultures, is frequently based on C-reactive protein values, which are considered a marker for neonatal sepsis. However, it is not known if C-reactive protein is elevated in some of these neonates due to the hypoxic ischaemic encephalopathic process and therefore these neonates might receive a longer duration of antibiotics …

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