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Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay
  1. Nagendra Monangi1,
  2. Jonathan L Slaughter2,3,
  3. Adekunle Dawodu4,
  4. Carrie Smith5,
  5. Henry T Akinbi1
  1. 1Neonatal Perinatal Medicine, Perinatal Institute, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, Ohio, USA
  2. 2Center for Perinatal Research and Ohio Perinatal Research Network, Nationwide Children's Hospital, Columbus, Ohio, USA
  3. 3Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
  4. 4Global Health Center, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, Ohio, USA
  5. 5University of Cincinnati Medical Center, Cincinnati, Ohio, USA
  1. Correspondence to Dr Henry T Akinbi, Division of Neonatology and Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA; henry.akinbi{at}cchmc.org

Abstract

Objectives To evaluate vitamin D (vitD) status in early preterm infants (EPTIs) at birth and during birth hospitalisation on current vitD intake.

Design/methods Serum 25-hydroxyvitamin-D [25(OH)D] concentrations, vitD intake and risk factors for low vitD status were assessed in 120 infants born at ≤32 weeks gestation.

Results Mean (SD) serum 25(OH)D at birth was 46.2 (14.0) nmol/L with lower concentrations in infants born <28 weeks than at 28–32 weeks gestation, p=0.02. Serum 25(OH)D was <50 nmol/L in 63% of mothers, 64% of infants at birth and 35% of infants at discharge. Mean daily vitD intake was 289±96 IU at 4 weeks of age and 60% achieved 400 IU/day intake at discharge.

Conclusions Serum 25(OH)D <50 nmol/L was widespread in parturient women and in EPTIs at birth and at discharge. Optimising maternal vitD status during pregnancy and improving postnatal vitD intake may enhance infant vitD status during hospitalisation.

  • Neonatology
  • Nutrition

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

https://doi.org/10.1136/archdischild-2013-303999

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