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Gastrointestinal viruses were not found as an aetiology of culture-negative illness in NICU patients
  1. Rimma Melamed1,
  2. Gregory A Storch2,3,
  3. Barbara B Warner4,
  4. Phillip I Tarr3,5
  1. 1Pediatric Division, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
  2. 2Division of Pediatric Infectious Diseases, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Missouri, USA
  3. 3Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
  4. 4Department of Pediatrics, Newborn Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
  5. 5Division of Gastroenterology and Nutrition, Departments of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri, USA
  1. Correspondence to Rimma Melamed MD; rimmam{at}bgu.ac.il

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Bloodstream infections are a significant cause of mortality and morbidity in premature and low-birth-weight infants; due to non-specific manifestations, ‘rule out sepsis’ evaluations are commonly performed in the age group. After evaluation, broad spectrum antibiotics are administered while awaiting the results of bacterial cultures that have a yield of not more than 25%–27%.1 ,2

Viral causes of sepsis-like syndromes in the neonatal intensive care unit (NICU) have been underexplored, especially in the PCR era. Because a large majority of putatively septic episodes fail to yield a bacterial pathogen, we hypothesised that culture-negative septic episodes in very low-birth-weight NICU patients might have a viral origin.

The objective of the study was to identify non-respiratory viral causes of sepsis-like illness.

Infants …

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