Increased time to pregnancy is associated with suboptimal neurological condition of 2-year-olds
- Jorien Seggers1,
- Pamela Schendelaar1,
- Arend F Bos2,
- Maas Jan Heineman3,
- Karin J Middelburg3,
- Maaike L Haadsma4,
- Mijna Hadders-Algra1
- 1Department of Paediatrics, Division of Developmental Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 2Department of Paediatrics, Division of Neonatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 3Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands
- 4Department of Genetics, Division of Clinical Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- Correspondence to Professor Mijna Hadders-Algra, Department of Paediatrics, Division of Developmental Neurology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands;
- Received 11 November 2012
- Revised 31 January 2013
- Accepted 1 February 2013
- Published Online First 25 March 2013
Objective To evaluate whether time to pregnancy (TTP) is associated with neurological condition of 2-year-old children born to subfertile parents.
Design Data collected in a prospective, assessor-blinded follow-up study were used for cross-sectional analyses.
Patients Participants were the singletons of the Groningen assisted reproductive technique cohort study: all children were born to subfertile couples (n=209). The active waiting TTP of the couples obtained from fertility charts was recorded in years and months, and was converted to decimal years.
Main outcome measure The presence of minor neurological dysfunction (MND), assessed with the Hempel examination.
Results MND was present in 16 (7.7%) children. TTP of children with MND (median 4.1, range 1.6–13.2) was significantly longer than that of children without MND (median 2.8, range 0.1–13.3; Mann-Whitney U test p=0.014). Logistic regression analysis on the contribution of TTP to MND resulted in a crude OR of 1.27 (95% CI 1.06 to 1.54). After correction for gestational age, parental age and parental level of education, the association remained statistically significant: OR=1.30 (95% CI 1.05 to 1.61).
Conclusions Increased TTP was associated with suboptimal neurological development in 2-year-old children. This suggests that subfertility and its determinants are involved in the genesis of neurodevelopmental problems.