Article Text

other Versions

PDF
Letters
Strategies to manage resistant gram-negative organisms in neonates
  1. Nimal Wickramasinghe1,
  2. Julie Suviste2,
  3. Mitul Patel1,
  4. Jim Gray1
  1. 1Department of Microbiology, Birmingham Women's Hospital, Birmingham, UK
  2. 2Department of Infection Control, Birmingham Women's Hospital, Birmingham, UK
  1. Correspondence to Dr Nimal Wickramasinghe, Department of Microbiology, Birmingham Women's Hospital, Mindelsohn Way, Edgbaston, Birmingham, West Midlands B15 2TG, UK; nwickramasinghe1{at}nhs.net

Statistics from Altmetric.com

Gram-negative antibiotic resistance is currently of major concern worldwide. In the UK, the prevalence of multi-resistant gram-negative bacteria (MRGNB) is increasing,1 and outbreaks have occurred in neonatal units (NNUs).

Up to 12% of neonates undergo a septic screen at birth, and most of them receive empiric antibiotics.2 Around 70% of NNUs use narrow-spectrum penicillin/gentamicin combinations for empiric treatment of neonatal sepsis.3 However, these regimens may not be active against MRGNB. Vergnano et al4 found that Enterobacteriaceae accounted for around 20% to 35% of early- and late-onset sepsis, respectively, underlining the threat that MRGNB pose in neonatology. Unlike many other …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.