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Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants
  1. Yona Amitai1,
  2. Cathy Hammerman2
  1. 1Department of Management, Public Health and Health Administration, Bar Ilan University, Ramat Gan, Israel
  2. 2Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
  1. Correspondence to Yona Amitai, Department of Management, Public Health and Health Administration, Bar Ilan University, Ramat Gan 52900, Israel yonaamitai89{at}gmail.com

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Barzilay et al1 stated recently that oral ibuprofen is more effective than intravenous ibuprofen for patent ductus arteriosus (PDA) closure. They attribute this superiority to pharmacokinetics; maintaining therapeutic plasma levels over a longer time extending the drug's therapeutic effect.

In an attempt to support their conclusion, they compare ibuprofen area under the curve (AUC) 0→24 generated by their study with data …

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