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Bifidobacterium septicaemia in an extremely low-birthweight infant under probiotic therapy
  1. Andreas Jenke1,
  2. Eva-Maria Ruf1,
  3. Thomas Hoppe2,
  4. Michael Heldmann1,
  5. Stefan Wirth1
  1. 1Department of Neonatology, HELIOS Children's Hospital, Wuppertal, Witten/Herdecke University, Germany
  2. 2Laboratoriumsmedizin Köln, Dres. Wisplinghoff, Cologne, Germany
  1. Correspondence to Andreas CW Jenke, Children's Hospital, Helios Klinikum Wuppertal,42283, Wuppertal, Germany; andreas.jenke{at}helios-kliniken.de

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Studies on probiotics for prevention of necrotising enterocolitis (NEC) show a risk reduction across all studies from 6.6% (165/2493) in the untreated to 2.5% (62/2433) in the treated patients.1 However, modest limitations in all studies, for example, uncharacteristically high-baseline rate of NEC2- warrant cautious risk–benefit consideration. This ambivalence is reflected by the current European Society of Paediatric Gastroenterology, Hepatology and Nutrition guidelines,3 not officially recommending their use whereas a recent cochrane review4 suggests a change in practice.

Monochorial-diamnial monocygotic twin pregnancy was diagnosed …

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