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Neonatal stroke
  1. M A Rutherford1,2,
  2. L A Ramenghi3,
  3. F M Cowan2,4
  1. 1Imaging Sciences Department, Imperial College and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
  2. 2Hammersmith/St Mary's Comprehensive Biomedical Research Centre, London, UK
  3. 3Fondazione Policlinico IRCCS Ospedale Cà Granda Neonatal Unit and NICU, Milan, Italy
  4. 4Division of Neonatology, Imperial College Healthcare Trust, London, UK
  1. Correspondence to M A Rutherford, Imaging Sciences Department, Imperial College and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK; m.rutherford{at}imperial.ac.uk

Abstract

Neonatal stroke encompasses a range of focal and multifocal ischaemic and haemorrhagic tissue injuries. This review will concentrate on focal brain injury that occurs as a consequence of arterial infarction, most frequently the left middle cerebral artery, or more rarely as a consequence of cerebral sinus venous thrombosis (CSVT). Both conditions are multifactorial in origin. The incidence of both acquired and genetic thrombophilic disorders in both mothers and infants is high although rarely causal in isolation. Neurodevelopmental morbidity occurs in over 50% of children. Specific therapy in the form of anticoagulation is currently only recommended in CSVT and needs to be carefully monitored in the presence of haemorrhage.

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  • Provenance and peer review Commissioned; externally peer reviewed.

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  • Review
    M A Rutherford L A Ramenghi F M Cowan