Article Text

other Versions

PDF
Unexpected collapse in apparently healthy newborns – a prospective national study of a missing cohort of neonatal deaths and near-death events
  1. Julie-Clare Becher1,
  2. Shetty S Bhushan2,
  3. Andrew J Lyon1
  1. 1Department of Neonatology, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
  2. 2Neonatal Unit, Ninewells Hospital, Dundee, UK
  1. Correspondence to Dr Julie-Clare Becher, Consultant Neonatologist, Department of Neonatology, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh EH16 4SA, UK; julie-clare.becher{at}luht.scot.nhs.uk

Abstract

Background Sudden and unexpected postnatal collapse (SUPC) of a healthy newborn infant is a rare event, which carries a high risk of mortality and significant neurodisability in survivors. An underlying condition can be found in 60% of cases who undergo detailed postmortem but in the remainder there are important associations with prone position, breast feeding and primiparous status. The authors undertook a prospective study to ascertain the population incidence of SUPC in the UK.

Methods Cases were referred through the British Paediatric Surveillance Unit reporting scheme over a 13-month period. Infants were at ≥37 weeks of gestation, had an Apgar score of ≥8 at 5 min, collapsed within 12 h in hospital requiring positive pressure ventilation and either died or received ongoing intensive care. Data were collected on maternal and infant characteristics, clinical investigations and 1-year outcome.

Findings 45 cases were reported, an incidence of 0.05/1000 live births of whom 12 infants died. In 15/45 infants, an underlying disease/abnormality was determined. In 30/45 cases (0.035/1000 live births), no such cause was found, but in 24, the clinical/pathological diagnosis was airway obstruction during breast feeding or in prone position. Mothers were commonly primiparous and unattended by clinical staff before collapse was recognised. Approach to investigation was highly disparate and frequently very limited. Of the 30 infants with no underlying disease/abnormality, 22 (73%) developed a postasphyxial encephalopathy and 10 had a poor outcome (33%) – 5 died and 5 had neurological sequelae at 1 year.

Interpretation SUPC is rare in any one centre and there is no standard approach to investigation. In those cases where collapse is not due to an underlying abnormality, breast feeding and prone position are important associations. Guidelines for safe postnatal care of infants should include appropriate vigilance of infants particularly where mothers are primiparous or where ability to assess the baby may be impaired.

Statistics from Altmetric.com

Footnotes

  • Funding The study was funded by WellChild from whom all authors are independent.

  • Competing interests (1) J-CB, SSB and AJL have support from WellChild for the submitted work; (2) J-CB, SSB and AJL have no relationships with any company that might have an interest in the submitted work in the previous 3 years; (3) their spouses, partners, or children have no financial relationships that may be relevant to the submitted work and (4) J-CB, SSB and AJL have no non-financial interests that may be relevant to the submitted work.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the National Research and Ethics Service (London REC Ref: 08/H0718/47).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.