Article Text

other Versions

PDF
Should the use of probiotics in the preterm be routine?
  1. Michael Millar1,
  2. Mark Wilks2,
  3. Paul Fleming2,
  4. Kate Costeloe3
  1. 1Department of Infection, London, UK
  2. 2Barts and The London NHS Trust, London, UK
  3. 3Neonatal Unit, Homerton University Hospital, London, UK
  1. Correspondence to Dr Michael Millar, Department of Infection, Barts and The London NHS Trust, Pathology and Pharmacy Building, 3rd Floor, 80 Newark St, Whitechapel, London E1 2ES, UK; m.r.millar{at}qmul.ac.uk

Abstract

Does the clinical trials' evidence of benefit justify the routine use of probiotics in the preterm infant? There are many uncertainties surrounding the use of probiotics in the preterm, including the mechanism(s) of action of probiotics, knowledge of who benefits and who might not, whether it is placement of large numbers of bacteria into the small intestine or colonisation that determines efficacy, the forms of microbial adaptation(s) and ecological consequences. There is also a current lack of defined products with associated evidence of safety in the preterm infant. It is argued that one cannot assume safety because of a lack of evidence of harm and that one should take a precautionary approach to the introduction of probiotics into routine neonatal practice. One should also consider how best one might monitor microbiological and ecological consequences and longer-term health outcomes before the introduction of this novel intervention into routine practice.

Statistics from Altmetric.com

Footnotes

  • Competing interests The authors are currently involved in a randomised placebo-controlled trial of a probiotic in preterm infants.

  • Provenance and peer review Commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.