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Prevalence of subclinical vitamin K deficiency in Thai newborns: relationship to maternal phylloquinone intakes and delivery risk
  1. Ampaiwan Chuansumrit1,*,
  2. Tassanee Plueksacheeva2,
  3. Sansanee Hanpinitsak3,
  4. Siwaponr Sangwarn2,
  5. Suthida Chatvutinun2,
  6. Umaporn Sutadvorawut1,
  7. Yongyoth Herabutya4,
  8. Martin Shearer5
  1. 1 Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;
  2. 2 Department of Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;
  3. 3 Mother and Child Health Region, Khonkaen, Thailand;
  4. 4 Dept. of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University,, Thailand;
  5. 5 Centre for Haemostasis and Thrombosis, St. Thomas’Hospital, London, Thailand
  1. Correspondence to: Ampaiwan Chuansumrit, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand; raajs{at}mahidol.ac.th

Abstract

Background: Vitamin K deficiency bleeding (VKDB) in infants is a rare but serious worldwide problem, particularly in Southeast Asia. Apart from exclusive breast-feeding, little is known of materno-fetal risk factors that predispose to VKDB.

Objectives: To assess (a) the relationships between functional vitamin K insufficiency in a large cohort of Thai mothers to that of their newborn infants and (b) the importance of delivery risk factors and maternal intakes of vitamin K as determinants of neonatal vitamin K status.

Methods: Vitamin K status was assessed by measuring undercarboxylated prothrombin (PIVKA-II) in 683 mothers and in the cord blood of their babies by sensitive immunoassay. Dietary phylloquinone (vitamin K1; K1) intakes were assessed in 106 of these mothers by food frequency questionnaire.

Results: Babies were categorized as ‘normal’ (n=590) or ‘high-risk’ (n=93) according to birth weight and delivery type. PIVKA-II was detectable (>0.15 Arbitrary Units (AU)/ml) in 85 mothers (12.4%) and 109 babies (16.0%) with median levels of 0.78 and 1.04 AU/ml in mothers and babies, respectively. ‘High-risk’ babies had both a higher median detectable PIVKA-II concentration than ‘normal-risk’ babies (3.1 vs. 1.0 AU/ml, p=0.02) and a higher prevalence of clinically relevant (>5.0 AU/ml) concentrations (p=006). Mothers with K1 intakes below the U.S. recommended ‘Adequate Intake’ for pregnancy (<90 µg/d) had a higher prevalence of detectable PIVKA-II (18.8%) than those with adequate intakes (3.3%) (p=0.01).

Conclusions: Functional, clinically relevant, vitamin K insufficiency was more common in ‘high-risk’ than ‘normal-risk’ newborns. Vitamin K insufficiency in mothers was linked to lower dietary K1 intakes during pregnancy.

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