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Rapid quantitative procalcitonin measurement to diagnose nosocomial infections in newborns
  1. Aurélien Jacquot (a-jacquot{at}chu-montpellier.fr)
  1. NICU, Arnaud de Villeneuve Hospital, Montpellier, France
    1. Jean-Marc Labaune
    1. NICU, La Croix-Rousse Hospital, Lyon, France
      1. Thierry-Pascal Baum
      1. Department of statistics, Arnaud de Villeneuve Hospital, Montpellier, France
        1. Guy Putet
        1. NICU, La Croix-Rousse Hospital, Lyon, France
          1. Jean-Charles Picaud
          1. NICU, Arnaud de Villeneuve Hospital, Montpellier, France

            Abstract

            Background and objective: Serum procalcitonin (PCT) monitoring may help clinicians to manage nosocomial infections in neonates. This study investigated the diagnostic value of a new, rapid method to measure PCT and sought to determine the best cutoff value.

            Methods: This monocentric, prospective study included all newborns with clinical suspicion of infection in a neonatal intensive care unit. Rapid, automated PCT measurements were performed on blood samples obtained for C-reactive protein (CRP) measurement. Negative and positive predictive values, sensitivity, and specificity were calculated. Logistic regression analysis determined the best cutoff value to obtain a negative predictive value of PCT that was at least 15% above that of CRP.

            Results: Between June 2005 and May 2006, 73 newborns with a gestational age of 28 [26-30] weeks (median [Q25-Q75]) and a birth weight of 995 [720-1350] g were included. Thirty (41%) were infected. The best PCT cutoff value was 0.6 ng/mL, which provided a negative predictive value of 100%. The sensitivity, specificity, and positive predictive value were 100%, 65%, and 67%, respectively, for PCT at the 0.6 ng/mL cutoff value.

            Conclusion: Rapid measurement of PCT could help to rule out nosocomial infection in newborns hospitalized in intensive care units.

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