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Very Preterm Children show Impairments across Multiple Neurodevelopmental Domains by Age 4 Years
  1. Lianne J Woodward (lianne.woodward{at}canterbury.ac.nz)
  1. University of Canterbury, New Zealand
    1. Stephanie Moor (stephanie.moor{at}otago.ac.nz)
    1. University of Otago, Christchurch, New Zealand
      1. Kelly M Hood (kmh35{at}student.canterbury.ac.nz)
      1. University of Canterbury, New Zealand
        1. Patricia R Champion (patricia.c{at}clear.net.nz)
        1. University of Canterbury, New Zealand
          1. Susan Foster-Cohen (susan{at}championcentre.org.nz)
          1. The Champion Centre, Burwood Hospital, New Zealand
            1. Terrie E Inder (inder_t{at}kids.wustl.edu)
            1. Washington University School of Medicine, United States
              1. Nicola C Austin (nicola.austin{at}cdhb.govt.nz)
              1. Christchurch Women's Hospital, New Zealand

                Abstract

                Objectives: Neurodevelopmental outcomes associated with preterm birth are of major health and educational concern. This study examined the neuromotor, cognitive, language and emotional/behavioural outcomes of a regional cohort of 4 year old children born extremely preterm (EPT: 23-27 weeks gestation), very preterm (VPT: 28-33 weeks) and full term (FT: 38-41 weeks). Of particular interest were children’s risks of impairment across multiple neurodevelopmental domains.

                Methods: Data were gathered as part of a prospective longitudinal study of 105 very preterm (<33 weeks gestation) and 107 full term children born during 1998-2000. At 4 years corrected age, children underwent a comprehensive, multidisciplinary assessment that included a paediatric neurological examination, cognitive and language testing, and an assessment of child emotional and behavioural adjustment.

                Results: At age 4 years, compared to full term children, EPT and VPT children had increased risks of cerebral palsy (EPT 18%, VPT 15%, FT 1%), cognitive delay (EPT 33%, VPT 36%, FT 13%), language delay (EPT 29%, VPT 29%, FT 10%) and emotional/behavioural adjustment problems (EPT 37%, VPT 13%, FT 11%). EPT and VPT children were three times more likely to have multiple domain impairments than full term children (EPT 30%, VPT 29%, FT 10%).

                Conclusions: A substantial proportion of preschool children born very preterm show clinically significant problems in at least one neurodevelopmental domain, with impairment in multiple domains being common. There is a need to monitor preschool development across a range of functional domains and to consider the likely cascading effects of multiple impairments on later development.

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