Article Text

other Versions

PDF
Neonatal Pasteurellosis: a review of reported cases
  1. Narongsak Nakwan (nnakwan{at}hotmail.com)
  1. Department of Pediatrics, Hat Yai Education Center, Hat Yai Hospital, Thailand
    1. Narongwit Nakwan
    1. Department of Medicine, Hat Yai Education Center, Hat Yai Hospital, Thailand
      1. Thitiya Atta
      1. Department of Pediatrics, Trang Hospital, Thailand
        1. Kulkanya Chokephaibulkit
        1. Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand

          Abstract

          Background: Pasteurellosis is an uncommon infectious disease in humans mainly caused by Pasteurella multocida infection in neonates was rarely reported.

          Objectives: To review the literature and address the mode of transmission, clinical presentation, laboratory diagnosis, treatment, and outcome, and potential risk factors related to neonatal pasteurellosis.

          Methods: A Medline all-languages database search for neonatal (birth-1 month) pasteurellosis cases after 1950 was conducted. Individual references from each publication were also reviewed to identify additional cases.

          Results: Thirty-two cases were found, but detail information was available for this review in only 25 cases. The median age was 14 days (range: birth-30 days). All were infected with P. multocida. Animal exposure to cats and/or dogs was the major risk of infection: non-traumatic exposure in 11 (44 %) cases, and traumatic exposure in 2 (8%) cases. Infections in eleven (44%) cases were classified as vertical transmission. The clinical features were most commonly bacteremia with or without meningitis. The age at onset of 72 hours or older was significantly associated with meningitis (≥ 72 hours of age: 13/14 vs. < 72 hours of age: 3/11, p = 0.002). The most used antibiotics were β-lactam with or without aminoglycoside or chloramphenical. The overall mortality was 20% (5/25). The age at presentation of < 72 hours, birth weight of < 2,500 g, and vertical transmission were independently associated with death.

          Conclusion: Pasteurellosis is a rare bacterial infection in neonates and should be considered in the cases of sepsis with history of exposure to domestic animal in either the patient or the mother.

          Statistics from Altmetric.com

          Request permissions

          If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.