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Attempt to improve transcutaneous bilirubinometry: a double blinded study Medick BiliMed versus Respironics BiliCheck
  1. Daniele De Luca (dm.deluca{at}fastwebnet.it)
  1. Catholic University of the Sacred Heart, Italy
    1. Enrico Zecca (enrizecca{at}rm.unicatt.it)
    1. Catholic University of the Sacred Heart,, Italy
      1. Mirta Corsello
      1. Catholic University of the Sacred Heart,, Italy
        1. Eloisa Tiberi
        1. Catholic University of the Sacred Heart,, Italy
          1. Carla Semeraro
          1. Catholic University of the Sacred Heart,, Italy
            1. Costantino Romagnoli (cromagnoli{at}rm.unicatt.it)
            1. Catholic University of the Sacred Heart,, Italy

              Abstract

              Objectives: To compare the accuracy of a new transcutaneous bilirubinometer (BiliMed® Medick SA, Paris, France) with BiliCheckTM (Respironics, Marietta, GA- USA), a widely available instrument, and with total serum bilirubin measurement.

              Design: We conducted a prospective double blinded study comparing two devices. 686 healthy newborns needing their bilirubin measured were enrolled over a 4 month-period. Serum and transcutaneous bilirubin measurements were taken with both devices within 15 minutes. The order of use of the instruments was randomized.

              Setting: Well-baby nursery ward in a University Hospital, tertiary referral centre.

              Results: The linear regression analysis showed a better correlation between BiliCheckTM and serum bilirubin (r = 0.75) than between BiliMed® and serum bilirubin (r = 0.45). BiliCheckTM variability (± 2 S.D. of the mean bias from serum bilirubin) was within -5.1/+3.7 mg/dl, while BiliMed® variability was within -5.7/+7.1 mg/dl. The ROC analysis (for serum bilirubin levels > 12 mg/dl or > 14 mg/dl) showed significantly higher areas under the curve for BiliCheckTM than those for BiliMed® ( p < 0.0001).

              Conclusions: Despite the potential practical advantages of BiliMed® , the reduced diagnostic accuracy in comparison to BiliCheckTM does not justify its use in clinical practice.

              • jaundice
              • newborn
              • transcutaneous bilirubin measurement

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