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Influence of maternal diabetes mellitus on fetal iron status.
  1. Alison Maria Verner (alison{at}verners.co.uk)
  1. Regional Neonatal Unit, Royal Jubilee Maternity Service, Belfast BT12 6BJ, Northern Ireland
    1. John Manderson
    1. Royal Jubilee Maternity Service, Belfast BT12 6BJ, Northern Ireland
      1. Terrence RJ Lappin
      1. Department of Child Health, Queen's University, Belfast, Northern Ireland
        1. David R McCance
        1. Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland
          1. Henry L Halliday
          1. Regional Neonatal Unit, Royal Jubilee Maternity Service, Belfast BT12 6BJ, Northern Ireland
            1. David G Sweet (david.sweet{at}royalhospitals.n-i.nhs.uk)
            1. Regional Neonatal Unit, Royal Jubilee Maternity Service, Belfast BT12 6BJ, Northern Ireland

              Abstract

              Objective: To determine the effects of maternal diabetes on fetal iron status using serum transferrin receptors (STfR) and their ratio to ferritin (TfR-F index) in cord blood.

              Methods:Iron, ferritin, erythropoietin, STfR and haemoglobin (Hb) concentration were measured and TfR-F index calculated in 97 maternal/cord blood pairs. Forty- nine women had type 1 diabetes (diagnosed before pregnancy) and these were compared with forty-eight non- diabetic controls. The women with type 1 diabetes were recruited consecutively from attendance at the joint antenatal endocrine clinic while the control group of women was recruited from consecutive attendance at the remaining antenatal clinics.

              Results: The infants of the diabetic women had significantly lower levels of ferritin (47 v 169 µg/l; p<0.01) and higher STfR (17.4 v 12.9 mg/l; p<0.01) and TfR-F index (10.4 v 5.8; p<0.01) than controls. They were also significantly more acidotic at birth (7.25 v 7.30; p<0.01), were born at an earlier gestation (36.7 v 39.7 wks; p<0.01) and had higher z scores for weight (0.53 v 0.02; p = 0.016).

              Conclusions: Maternal diabetes causes increased depletion of fetal iron stores and is associated with higher fetal iron demands as indicated by higher STfR level and TfR-F index in cord blood. Key Words: ferritin, STfR, TfR-F index.

              • STfR
              • TfR-F index
              • ferritin

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