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PPO.30 Assessment of adverse perinatal outcomes in women with isolated PAPP-A <0.3 at firt trimester screening
  1. K Skorupskaite,
  2. L Stirrat,
  3. N Palaniappan,
  4. C Shearing,
  5. S Cowan
  1. Simpsons Centre for Reproductive Health, New Royal Infirmary of Edinburgh, Edinburgh, UK

Abstract

Background Maternal serum pregnancy-associated-plasma-protein-A (PAPP-A) was introduced as a part of combined first trimester trisomy 21 screening (nuchal translucency, PAPP-A and human chorionic gonadotropin) in 2011. We aimed to investigate whether isolated low PAPP-A (< 0.3MoM) was associated with stillbirth, preterm delivery and low birthweight in women booked for delivery in NHS Lothian in 2011.

Methods We retrospectively reviewed case records of women with low PAPP-A level during 2011 (n = 154). Rate of stillbirth, preterm delivery and low birthweight were compared with a control group (n = 9603) who had a normal PAPP-A result, or had opted out of screening. Chi-squared test was used for comparison of rates. Statistical significance was considered at p < 0.05.

Results Rates of stillbirth, preterm delivery and low birthweight were significantly higher in women with low PAPP-A (Table 1).

Abstract PPO.30 Table 1

Conclusions Our results suggest that low PAPP-A at first trimester screening is associated with significantly higher rates of stillbirth, preterm delivery and low birthweight.

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