Background Antenatal thrombocytopenia occurs in 5% of pregnancies and is predominantly due to gestational thrombocytopenia (GTP), or more rarely is immunologically-mediated (ITP). The risk of significant neonatal thrombocytopenia (<50 × 109/L) has been suggested as 5–10% in women with ITP, although risk of bleeding is low. The aim of this study was to report pregnancy outcomes of women with thrombocytopenia in a large UK tertiary referral centre.
Methods Pregnant women with platelet counts ≤ 120 × 109/L were identified retrospectively from the laboratory records between December 2011 and December 2012. Pregnancy and neonatal records were examined and data collected.
Results Laboratory records identified 215 women with a platelet count ≤ 120 × 109/L during pregnancy. 118/215 (55%) were excluded due to pre-eclampsia, sepsis or post-partum haemorrhage. 100 infants were born to 97 women, 25 (26%) delivered by Caesarean section. 17 had presumed GTP, 30 ITP, with 50 being of unknown cause antenatally. 10/98 (10.2%) had a blood loss greater than 1000mls, comparable to the hospital population (9.2%). Neonatal platelet counts were available 69/101(68%) babies. 19/69 (27.5%) had thrombocytopenia <150 × 109/L, with 3 (4.3%) <50 × 109/L. There was one report of a small non-significant intraventricular haemorrhage (platelets 12 × 109/L). Maternal platelet count did not correlate with either blood loss or neonatal platelet count.
Conclusions Whilst neonatal thrombocytopenia was relatively common (27.5%), clinically significant neonatal thrombocytopenia was rare which is reassuring for women. Low maternal platelets did not increase the risk of postpartum haemorrhage.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.