Article Text

PDF
Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial
  1. Mehmet Yekta Oncel1,
  2. Fatma Nur Sari1,
  3. Sema Arayici1,
  4. Nilufer Guzoglu1,
  5. Omer Erdeve2,
  6. Nurdan Uras1,
  7. Serife Suna Oguz1,
  8. Ugur Dilmen1,3
  1. 1Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
  2. 2Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
  3. 3Department of Pediatrics, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
  1. Correspondence to Dr Mehmet Yekta Oncel, Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, Altındag, Ankara, Turkey; dryekta{at}gmail.com

Abstract

Objective To evaluate the effect of oral Lactobacillus reuteri (L reuteri) first on the incidence and severity of Necrotising enterocolitis (NEC) and second on sepsis.

Design Prospective randomised controlled study.

Setting Tertiary neonatal intensive care unit.

Patients and interventions Preterm infants with a gestational age of ≤32 weeks and a birth weight of ≤1500 g were included (n=400). Infants in the first group were given 100 million CFU/day (5 drops) of lyophilised L reuteri (DSM 17938) mixed in breast milk or formula, starting from first feeding until discharge. Participants in the control group were given a placebo.

Main outcome measures To determine and compare the frequency of NEC and/or death after 7 days, frequency of proven sepsis, rates of feeding intolerance and duration of hospital stay.

Results There was no statistically significant difference between groups in terms of frequency of NEC stage ≥2 (4% vs 5%; p=0.63) or overall NEC or mortality rates (10% vs 13.5%; p=0.27). Frequency of proven sepsis was significantly lower in the probiotic group compared to the control group (6.5% vs 12.5%; p=0.041). A significant difference was also observed with regard to rates of feeding intolerance (28% vs 39.5%; p=0.015) and duration of hospital stay (38 (10–131) vs 46 (10–180) days; p=0.022).

Conclusions Our results show that oral L reuteri does not seem to affect the overall rates of NEC and/or death in preterm infants followed up in the neonatal intensive care unit, and significant reductions were observed in the frequency of proven sepsis, rates of feeding intolerance and duration of hospital stay.

Trial registration number NCT01531179.

  • Feeding intolerance
  • lactobacillus reuteri
  • necrotizing enterocolitis
  • preterm infant

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Fantoms
    Ben Stenson