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PF.14 Isolated Borderline Fetal Cerebral Ventriculomegaly – Role of Magnetic Resonance Imaging (MRI)
  1. JW Gabriel1,
  2. R Dworkin1,
  3. M To2,
  4. S Bower2,
  5. N Zosmer2,
  6. R Akeolar3,
  7. N Flack2
  1. 1King’s College London, London, UK
  2. 2King’s College Hospital, London, UK
  3. 3Medway Maritime Hospital, Medway, UK

Abstract

Objective To examine the role of third trimester magnetic resonance imaging (MRI) in fetuses diagnosed with isolated borderline cerebral ventriculomegaly at the routine second trimester fetal anomaly scan.

Methods This was a retrospective cohort study of 159 fetuses with apparently isolated borderline ventriculomegaly (9–12 mm) diagnosed at the routine second trimester ultrasound scan at a median of 22 (range 19–24) weeks’ gestation and no additional findings at a repeat scan 6–8 weeks later. Follow up cerebral MRI was carried out at 28–34 weeks and the number of cases in which this investigation demonstrated abnormal findings was calculated. The patients were examined in a tertiary fetal medicine unit between 2005 and 2012.

Results In 7 (4.4%) of the 159 cases the MRI scan demonstrated findings not seen by ultrasound. These included partial agenesis of the corpus callosum (n = 2), delayed sulcation disorders (n = 1), heterotopia (n = 2), germinal matrix haemorrhage (n = 1), and destruction of the septum pellucidum (n = 1).

Conclusions In about 4% of fetuses with apparently isolated borderline cerebral ventriculomegaly an MRI scan demonstrates potentially clinically significant pathological findings.

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