Intravitreal anti-vascular endothelial growth factor for ROP

This highly informative review article by Darlow et al reviews the scientific background for the use of intravitreal anti-vascular endothelial growth factor for the treatment of retinopathy of prematurity and places the findings of the BEAT-ROP trial of Bevacizumab in the context of evolving knowledge in this subject area. Although the treatment results in impressive effects on the eyes, there is a great deal to learn. Because these agents enter the systemic circulation and suppress vascular endothelial growth factor (VEGF) levels systemically there is significant potential for adverse effects on other developing organs. Emerging evidence from the trials of different oxygen saturation target ranges is giving rise to renewed caution over the use of lower saturation targets to prevent ROP, so the condition is here to stay for the time being. The need to contain enthusiasm for a new approach until …