Arch Dis Child Fetal Neonatal Ed 98:F94 doi:10.1136/archdischild-2012-302044
  • PostScript

An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants

  1. Ugur Dilmen1
  1. 1Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
  2. 2Department of Pediatric Cardiology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
  1. Correspondence to Mehmet Yekta Oncel, Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Hamaönü, Altındagğ, Ankara 06110, Turkey; dryekta{at}
  1. Contributors Oncel M Y and Uras N designed research; Oncel M Y, Yurttutan S, Ozdemir R and Ekmen S conducted research and followed by patients; Altug N made echocardiography. Oncel M Y and Erdeve O wrote the paper. Dilmen U had primary responsibility for final content. All authors read and approved the final manuscript.

  • Received 14 March 2012
  • Accepted 4 April 2012
  • Published Online First 18 May 2012

The most commonly used drugs for closure of a haemodynamically significant patent ductus arteriosus (hsPDA) are cyclooxygenase inhibitors, mainly indomethacin and intravenous/oral ibuprofen. In contrast to high closure rates, several adverse effects have been reported with such medications, including gastrointestinal bleeding and perforation, weakened platelet aggregation, hyperbilirubinaemia and renal failure.1 ,2 The role of paracetamol as an …

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