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An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants
  1. Mehmet Yekta Oncel1,
  2. Sadik Yurttutan1,
  3. Nurdan Uras1,
  4. Nahide Altug2,
  5. Ramazan Ozdemir1,
  6. Sadrettin Ekmen1,
  7. Omer Erdeve1,
  8. Ugur Dilmen1
  1. 1Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
  2. 2Department of Pediatric Cardiology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
  1. Correspondence to Mehmet Yekta Oncel, Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Hamaönü, Altındagğ, Ankara 06110, Turkey; dryekta{at}gmail.com

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The most commonly used drugs for closure of a haemodynamically significant patent ductus arteriosus (hsPDA) are cyclooxygenase inhibitors, mainly indomethacin and intravenous/oral ibuprofen. In contrast to high closure rates, several adverse effects have been reported with such medications, including gastrointestinal bleeding and perforation, weakened platelet aggregation, hyperbilirubinaemia and renal failure.1 ,2 The role of paracetamol as an …

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