The impact of oral sucrose on apnea and bradycardia in preterm infants: a randomised cross-over trial
- 1Department of Neonatology, Tuebingen University Hospital, Tuebingen, Germany
- 2Center for Pediatric Clinical Studies, Tuebingen University Hospital, Tuebingen, Germany
- Correspondence to Dirk Bassler, Tuebingen University Hospital, Department of Neonatology, Tuebingen 72076, Germany;
Contributors The study protocol was developed by Tanja Karen, Christian Poets, Christoph Maas and Dirk Bassler. Data were collected by Scarlet Vatlach and Anette Poets. Data analysis was done by Scarlet Vatlach, Anette Poets and Dirk Bassler. The first draft of the manuscript was done by Tanja Karen. All authors reviewed and approved the final version of the manuscript.
- Received 27 February 2012
- Accepted 9 May 2012
Pain may promote apnea of prematurity (AOP).1 Oral sucrose is effective for analgesia2 but no study has investigated its effect on the prevention of AOP.
Our ethics committee approved the study and we obtained informed consent. Patient inclusion criteria were: gestational age < 32 weeks, chronological age at study entry ≥ 10 days and postmenstrual age < 36 weeks, caffeine and nasal continuous positive airway pressure (CPAP); need for additional oxygen < 30%, median apnea score ≥ 5 per …