Arch Dis Child Fetal Neonatal Ed 98:F89-F92 doi:10.1136/archdischild-2011-300641
  • Reviews

What are the main research findings during the last 5 years that have changed my approach to clinical practice?

  1. Christian F Poets
  1. Correspondence to Professor Christian F Poets, Department of Neonatology, Tuebingen University Hospital, Tuebingen D-72076, Germany; christian-f.poets{at}
  1. Contributors CFP was involved in collecting the manuscripts reviewed in this article and in writing it.

  • Accepted 20 July 2011
  • Published Online First 24 August 2011


When asked to address the above question, findings that appeared to be among the most relevant included (1) interventions in the delivery room directed at supporting the physiological transition from intrauterine to extrauterine life rather than actively intervening in it; (2) recent data suggesting that keeping extremely low-gestational age neonates at a pulse oximeter saturation (SpO2) of 91–95% would increase their chances of survival compared with aiming for lower SpO2 values; (3) using caffeine citrate in infants <1250 g with apnoea of prematurity improves neurodevelopmental outcome; (4) injecting antivascular epithelial growth factor into the vitreous seems to be an effective treatment for retinopathy of prematurity and (5) moderate hypothermia for perinatal hypoxic-ischaemic encephalopathy increases the likelihood of survival without neurological impairment. Here, data that support these recent changes in approach will be presented and discussed.


  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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