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Labour and Delivery Posters
The use of fetal fibronectin from 18 weeks in the prediction of preterm birth in high-risk asymptomatic women
  1. S Radford1,2,
  2. D Abbott1,
  3. P Seed1,
  4. P Snow2,
  5. A Shennan1
  1. 1King's College London, London, United Kingdom
  2. 2Monash University, Melbourne, Australia

Abstract

Spontaneous Preterm birth (sPTB), is the leading cause of neonatal mortality and accounts for approximately 10% of all births worldwide. Fetal fibronectin (fFN) sampled between 22-35 weeks gestation is the strongest predictor of PTB.

Objectives This study investigated the potential for fFN to predict PTB in high-risk asymptomatic women from 18 weeks gestation, earlier than fFN has been previously used clinically.

Study design A prospective observational study of 113 high-risk asymptomatic participants that were recruited through St. Thomas' hospital high-risk antenatal clinics, the preterm surveillance clinic, the antenatal ward and the antenatal day assessment unit. Participants acted as their own controls and had tests taken between 18-22 weeks and within the standard testing period of 22-35 weeks. Outcome measures were spontaneous delivery before 30, 34 and 37 weeks gestation and within 8 weeks of conducting the test.

Results fFN samples taken from 18 weeks showed a strong and significant predictive value for the prediction of PTB at all end-points (Table 1) with the strongest predictive value being for delivery before 30 weeks gestation. fFN sampled between 18-22 weeks was equivalent to tests taken beyond 22 weeks in the standard testing period. Both testing periods produced 100% sensitivity, 82% specificity and receiver operator characteristics (ROC) areas above 0.9.

Conclusion fFN screening is valid for the prediction of PTB from 18 weeks in high-risk asymptomatic women allowing for earlier identification and targeted management.

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