Article Text

PDF
Maternal Medicine Posters
Spontaneous platelet aggregation (SPA) predicts pre-eclampsia and intra-uterine growth restriction
  1. N Burke1,4,
  2. A Murray1,4,
  3. E Dunne2,
  4. P Dicker3,
  5. M Dempsey4,
  6. H O’Connor4,
  7. Z Fonseca-Kelly4,
  8. B Cotter1,2,
  9. M Geary4,
  10. K Flood1,
  11. D Kenny2,
  12. F Malone1,4
  1. 1Dept. of Obs and Gynae., Royal College of Surgeons in Ireland, Dublin, Ireland
  2. 2Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
  3. 3Dept. of Epidemiology, Royal College of Surgeons in Ireland, Dublin, Ireland
  4. 4Rotunda Hospital, Dublin, Ireland

Abstract

Platelet function has not been well characterised in pregnancy. We used a modification of light transmission aggregometry to prospectively assess SPA in normal and complicated pregnancies. The study was powered (80%) to detect a 6% change in platelet aggregation across the time-points and an 8% change for PET or IUGR.

In 50 patients with normal pregnancy, platelet function was assessed in the three trimesters and post-natally. In 35 patients with pre-eclampsia (PET) and 18 patients with intra-uterine growth restriction (IUGR) platelet function was assessed in the third trimester. Comparisons between platelet function assays in the four time points of normal pregnancy were made using a mixed effects model with study participant as a random-effect, allowing for possible correlations between the repeated assessments. ANOVA was used to compare these assessments with the PET and IUGR groups. The results are presented as Bonferroni adjusted p-values.

SPA increased significantly between the 1st and 2nd trimester (7% increase, p-value=0.0001); the 3rd trimester (9% increase, p-value=0.0020) and the post-natal assessment (15% increase, p-value=0.0002) in normal pregnancy. In contrast there was no increase in the platelet aggregation profile of patients with either PET or IUGR.

We demonstrate for the first time a significant incremental increase in SPA with advancing gestational age in normal pregnancy. In contrast this increase in platelet aggregation does not occur in the third trimester in platelets from patients with either PET or IUGR. These results suggest that sequential analysis of SPA may be a novel marker for at risk pregnancies.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.