Article Text

PDF
Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding
  1. Carol Dryden1,
  2. David Young2,
  3. Nicole Campbell1,
  4. Helen Mactier1
  1. 1Neonatal Unit, Princess Royal Maternity, Glasgow, Scotland, UK
  2. 2Department of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland, UK
  1. Correspondence to Helen Mactier, Neonatal Unit, Princess Royal Maternity, 16 Alexandra Parade, Glasgow G31 2ER, Scotland, UK; helen.mactier{at}ggc.scot.nhs.uk

Abstract

It is widely accepted that maternal drug-exposed infants demonstrate excessive early weight loss, but this has not previously been quantified. Among 354 term, substitute methadone-exposed infants, median maximal weight losses were 10.2% and 8.5% for breast- and formula-fed infants, respectively (p=0.003). Weight loss was less in small for gestational age compared to appropriately grown infants (p<0.001). There was no association between maximal weight loss and plasma sodium concentration (p=0.807). Relative to non-drug exposed infants, weight loss was more marked in formula-fed infants, 48% of whom demonstrated weight loss in excess of the 95th centile (compared to 23% of exclusively breastfed infants; p<0.001). Median weight loss nadir was on day 5, excepting those infants exclusively breastfed (day 4). These data suggest that excessive neonatal weight loss among breastfed infants of drug-misusing mothers does not necessarily reflect poorly established lactation and may help to guide management of breast feeding in this population.

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the local ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.