Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. In the non-pregnant patient D-Dimer testing has a role as a negative predicator of thrombosis. This is not a recognised test in pregnancy as D-Dimer concentration increases progressively from conception until delivery.
The aim of this study was to establish reference values for D-Dimers in the first trimester of normal pregnancy and compare these ranges to the normal non-pregnant range.
D-Dimer measurements were carried out on 164 low risk women carrying singleton pregnancy in their first trimester. Samples were analysed using Bio-pool Auto-Dimer Assay.
Data from a previous study establishing normal (non-pregnant) ranges of D-Dimer using the same assay were compared with data obtained from these 164 pregnant women.1 Table shows the differences observed between the two populations. There is a clear increase in D-Dimer levels for pregnant women, with the 5th and 95th centiles increased to 39 and 500 ng/ml respectively. There was no significant trend of D-Dimer across gestational age in first trimester.
The results support findings from previous studies reporting a progressive increase in D-Dimer levels during normal pregnancy. The recommended cut off in the diagnosis of VTE for pregnant women in the first trimester based on this study is 500 ng/ml rather than 224 ng/ml
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.