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Neonatal encephalopathy is the subject of four interesting articles in this issue. An increasing body of research challenges the traditional view that infants with neonatal encephalopathy secondary to perinatal asphyxia who do not develop cerebral palsy escape unharmed. The subject is reviewed by de Vries and Jongmans (see page 220). This evidence that cognitive and memory difficulties occur in the absence of motor abnormalities indicates that many more studies with follow up well beyond early infancy are required to characterize fully the continuum of hypoxic ischaemic brain injury.
Now that cooling for hypothermia is becoming a standard of care for infants with hypoxic ischaemic encephalopathy, Malcolm Levene provides an excellent overview of some of the potential additional treatments …
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